The baboon is not an adequate model for endometriosis
It is a pity we do not have an adequate animal model for endometriosis.I therefore started with the help of the EU the baboon project in Kenya at the IPR. This was done under direct supervision of Chandrit Bambra and Mohamed Isahakia by Thomas D’Hooghe who used the data for his PhD with myself and Bambra as promotors. Since then, after several years, is has become clear that the baboon is not an adequate model for endometriosis .
First, baboons do have endometriosis but we found only minimal superficial lesions. In the first articles the point scoring system of the rAFS has been multiplied by 2 with the argument that the baboon is small. This mistake has been repeated systematically later on and I only realised afterwards that without this almost all animals would have been classified as class I and that almost all significances in results would disappear in the articles.
Baboons with severe endometriosis as deep and cystic ovarian endometriosis are not available for research. These lesions have been observed only occasionally in primates and we were unable to induce these lesions in baboons even not using immunosuppressive drugs, experiments that were pretty expensive.
Only typical lesions could be induced by injecting menstrual endometrium, but whether this would be useful as a model remains unexplored.
The published results should be interpreted with caution. The over 20 articles (in all of of them I am the last author except the last 2) are based only on some 250 laparoscopies in 50 baboons. Reassesing the articles I realised that although all articles have been published as significant at the 0.05 level, all significances are based on 1 animal only and will disappear if one animal would have been misclassified. Looking backwards this is surprising. In addition, in the last 2 articles I refused to be a co-author because of lack of internal consistency of the data.
At he end of the experiments, most of the baboons died from tuberculosis, making repeat experiments virtually impossible.
It was described in the baboon that TNFa was effective for endometriosis treatment, but this was not confirmed in the human.
The baboon therefore cannot be considered as an adequate model for endometriosis, something I have been telling repetitively at international meetings. To publish this message as a comment in the peer reviewed literature, however, remains difficult since comments only are not acceptable for publication. Thus eventual mistakes tend to be carried forward, and doubt will continue until the day the experiments are repeated and confirmed or not.
Prof P.R. Koninckx
Tags: animal models, baboon, Endometriosis, pathopysiology
November 18th, 2009 at 11:32 am
Just wanted to say thanks for all the great info found on your blog, even helped me with my job recently
keep it up!
November 18th, 2009 at 3:24 pm
I only want to tell you thanks for all the great info found on your site, even helped me with my work recently
keep it up!
November 26th, 2009 at 9:06 am
Good job! Can’t wait to start my own blog.
December 13th, 2009 at 9:08 am
Easily, the post is really the best on this noteworthy topic. I harmonize with your conclusions and will thirstily look forward to your incoming updates. Saying thanks will not just be enough, for the wonderful lucidity in your writing. I will immediately grab your rss feed to stay informed of any updates with my appendicitis review website.Gratifying work and much success in your business dealings!Thanks.
December 30th, 2009 at 3:54 am
Good Day!!! http://www.gynsurgery.org is one of the best informational websites of its kind. I take advantage of reading it every day. http://www.gynsurgery.org rocks!
January 9th, 2010 at 2:10 pm
I admire the valuable information you offer in your articles.Just thought you’d be interested to know that I have added you to my bookmarks You make 100% valid points in a concise and pertinent fashion, This is a really good read for me, many thanks to the author
January 22nd, 2010 at 1:21 pm
I enjoy reading the valuable information you offer in your articles.I enjoying reading your post. You make 100% right points in a concise and pertinent fashion, I will read more of your stuff, many thanks to the author
January 24th, 2010 at 1:55 pm
Very good blog post I enjoy your site keep up the amazing blog posts
January 27th, 2010 at 11:54 pm
Hmm… Interesting! I always love reading the posts on this website. …
I think that that was really interesting. Good post! …
February 8th, 2010 at 4:18 am
That’s good article about this good post. It’s useful to go to the essay writing services that would like to make the essay writing and custom essay. Thus people could purchase essay.
February 12th, 2010 at 3:05 am
I am completely impressed with the article I have just read. I wish the writer of http://www.gynsurgery.org can continue to provide so much worthwhile information and unforgettable experience to http://www.gynsurgery.org readers. There is not much to tell except the following universal truth: The existence of universal truths is based on the non existence of cultural relativism. I will be back.
February 14th, 2010 at 9:32 am
Can I use an excerpt from your post on my blog? I think my readers would appreciate it. I will give you a link back so you can get credit. let me know please.
February 14th, 2010 at 10:14 am
Amiable brief and this fill someone in on helped me alot in my college assignement. Say thank you you as your information.
February 18th, 2010 at 4:58 pm
Whats up! Great thought, but will this really do the job?
Robert
February 18th, 2010 at 7:46 pm
You’re soooo gifted in writing. God is really using you in tremendous methods. You’re doing a great job! This was an awesome blog!
February 19th, 2010 at 7:32 pm
Kudos for posting such a useful weblog. Your blog isn’t only informative but also extremely artistic too. There usually are very couple of individuals who can write not so simple articles that creatively. Keep up the good writing !!
February 19th, 2010 at 7:37 pm
Hello, I attempted to e-mail you regarding this post that i’ve some inquires, but can’t seem to reach you. Please email me when have a minute. Thanks.
February 20th, 2010 at 9:42 am
Loved reading this article, thank you! Bookmarked your blog
March 4th, 2010 at 9:34 pm
Great Post!…
[..] A little unrelated, but I rather liked this webpage post [..]…
March 4th, 2010 at 10:55 pm
Good job on your blog.
March 15th, 2010 at 8:23 am
Genial post and this post helped me alot in my college assignement. Thank you seeking your information.
March 15th, 2010 at 11:57 am
Nice site! I adore a few of the articles that have been written, and especially the comments posted! I will definately be visiting again!
March 20th, 2010 at 11:38 am
I really liked your blog! super
March 21st, 2010 at 7:09 pm
Substantially, the post is in reality the freshest on this notable topic. I fit in with your conclusions and will eagerly look forward to your incoming updates. Saying thanks will not just be sufficient, for the fantasti c lucidity in your writing. I will at once grab your rss feed to stay informed of any updates.De lightful work and much success in your business endeavors!Thanks.
March 22nd, 2010 at 4:52 pm
Pretty insightful post. Never thought that it was this simple after all. I had spent a good deal of my time looking for someone to explain this subject clearly and you’re the only one that ever did that. Kudos to you! Keep it up
March 23rd, 2010 at 5:55 am
Understandably your article helped me altogether much in my college assignment. Hats high to you enter, intention look progressive for more related articles without delay as its anecdote of my choice issue to read.
March 24th, 2010 at 7:27 pm
Genial brief and this fill someone in on helped me alot in my college assignement. Thanks you seeking your information.
March 29th, 2010 at 9:13 pm
comment…
Приятно читать блог…
March 30th, 2010 at 5:49 pm
My name is Piter Jankovich. oOnly want to tell, that your blog is really cool
And want to ask you: is this blog your hobby?
P.S. Sorry for my bad english
March 30th, 2010 at 11:07 pm
Can you provide more information on this? cheers
March 31st, 2010 at 10:39 am
I think patients deserve honest information
April 5th, 2010 at 7:52 pm
Every time I come to http://www.gynsurgery.org you have another fascinating post up. A friend of mine was talking to me about this topic several weeks ago. I think I will send my friend the url here and see what they say.
April 5th, 2010 at 8:25 pm
……
Бизнесмен из Вас отличный…
April 6th, 2010 at 8:15 am
It appears that you have placed a lot of hard work into your post and I require much more of these using the net in recent times. I sincerely got a kick out of your post. I don’t really have much to express in response, I only wanted to comment to reply amazing work.
April 23rd, 2010 at 9:28 am
[...] grants : a majority of specialists . The absence of an animal model is greatly hampering reseach. Also the baboon, which I evaluated is not a useful model since severe forms do not occur and cannot … Evidence Based Medecine is an argument often used against surgery since RCT are rare. It is beyond [...]
May 9th, 2010 at 8:48 pm
hello it is my first post on this website and firstly I would like to thank for the great quality information, which I found in this and all previous posts , it really helped me very much. I will definitely put this website on my rss reader
Also, I would like to ask – don’t you mind if I will quate some information from your blog because I am writing articles for the Bukisa, Ezine and other articles directories (this is my part time job)? It would really help me with some of mine articles. Of course, I will mention your website name or URL (not all articles directories allows URL’s , so I can’t 100% promise that you will get a direct backlink to your blog).
May 21st, 2010 at 2:44 am
This is far the best article about this topic. I have this site under my bookmarks soon so long.
October 21st, 2010 at 11:20 am
I read some thing related to your post via google news… I became interested and then started searching around, and then landed at this page… anyhow, I feel that I somewhat agree with what you cover here. However I’m going to go see what else I can find too.