+32 16 462796 pkoninckx@gmail.com

Peer reviewed publications of the Gruppo Italo Belga


The 250+ publications on pubmed

A full update of our peer reviewed publications can be found on PUBMED.

Read full text of selected publications ; ask for a personal pdf copy on “contacts”


2018 the genetic -epigenetic theory

2018 the genetic-epigenetic theory explains the pathophysiology of endometriosis. it explains why endometriosis is hereditary and the pregnancy associated problems

2018_pandora box of endometriosis treatment

2018_The pandora box of endometriosis treatment explains the mistakes made during surgical and during medical treatment

Endometriosis and adenomyosis

Endometriosis and adenomyosis are associated. This is not surprising considering the genetic-epigenetic theory

endometriosis and pregnancy

Endometriosis and pregnancy outcome. The mechanism is explained by the genetic-epigenetic hypothesis. The clinical consequence is that a pregnancy in women with severe endometriosis should be considered a high risk pregnancy.

2018 Reproductive surgery

2018 Reproductive surgery and Ivf are complementary but a diagnostic laparoscopy comes first with surgery if the gynecologist has the skills

The best surgeons knot in endoscopic surgery

The best surgeons knot in endoscopic surgery explains how to make secure knots


2017_ussia_spigelian hernia

2017_ussia A spigelian hernia is knowm since the 1500’s but is pooly known in gynecology as a cause of (pelvic) pain

2017_gordts_pathogenesis of deep endometriosis

2017_gordts et al.  Describes the implantation theory and the genetic epigenetic theory as 2 opposing alternatives.

2017_pk_ebm  versus clinical opinion

2017_pk. The misperceptions of evidence based medicine are explained together with the value of the clincial opinion of experts


2017_de wilde _adhesion prevention

2017_de wilde _ An expert opinion on adhesion prevention today.



A comment written for the Canadian J of OBGYN explains that guidelines based on published evidence only is half the clinical truth

2017_corona  n2o in open surgery

2017_corona.  N2o is the single most effective prevention of adhesion formation also in open surgery



2016_pk_A views ans reviews introduction about adhesion prevention during surgery


2016_pk_Microscopic endometriosis is not a pathology and is found in the normal looking peritoneum and in the bowel at distance form a nodule.



2016_pk_Peritoneal conditioning is the most important aspect of adhesion prevention during surgery


2016_pk_The epidemiology of endometriosis is poorly explored. Howevere the endometriosis surgeons strongly suspect an increase in deep endometriosis


2015_verguts _clearance rates

2015_verguts _Clearance rates of Ringers lactate are less after conditiong, which confirms the anti-adhesiogenic effect of conditioning

2015_pk_n2o under  local anaesthesia

2015_pk_The addition of 10% of N2O to the pneumoperitoneum permits to perform laparoscopy under local anaesthesia

2015_de cicco_lavage

2015_de cicco. A thorough lavage with 8 liters prevents the complication after a bowel perforation


2014_setubal_bowel complic

2014_setubal_During pregnancy severe bowel complications occur in women with deep endometriosis. This is the first evidence of heterogeneity of endometriosis


2014_binda_tumour implantion is reduced by conditioning

2014_binda_The efficacy of conditioning is demonstrated by decreasing tumour implantion in mice

2013pk_conditioning decreases adhesion formation

2013pk Conditioning strongly decreases adhesion formation: a RCT in the human


2013_wallwiener_adhesion awareness

2013_wallwiener_Adhesion awareness

2013_corona_n2o open

2013_corona_N2O decreases adhesion formation

2013_pk_Digital operating room

2013_pk_consensus endometriosis

2013_pk_This is an opinion paper on endometriosis but in the absence of surgeons


De Wilde RL, Brolmann H, Koninckx PR, Lundorff P, Lower AM, Wattiez A et al. Prevention of adhesions in gynaecological surgery: the 2012 European field guideline. Gynecol Surg. 2012;9:365-368.




The impact of the learning curve on adhesion formation in a laparoscopic mouse model. Corona R, Verguts J, Binda MM, Molinas CR, Schonman R, Koninckx PR. Fertil Steril. 2011 Jul;96(1):193-7.


Koninckx, P. R., Ussia, A., Addison, A., and Wattiez, A. An endometriosis classification, designed to be validated. Gynecol Surg. 8, 1-6. 2011.


Intraperitoneal temperature and desiccation during endoscopic surgery. Intraoperative humidification and cooling of the peritoneal cavity can reduce adhesions. Corona R, Verguts J, Koninckx R, Mailova K, Binda MM, Koninckx PR.
Am J Obstet Gynecol. 2011 Oct;205(4):392.e1-7.


Laparoscopic ureteral repair in gynaecological surgery. De Cicco C, Ussia A, Koninckx PR. Curr Opin Obstet Gynecol. 2011 Aug;23(4):296-300. Review.


Carbon dioxide pneumoperitoneum prevents postoperative adhesion formation in a rat cecal abrasion model. Verguts J, Corona R, Binda MM, Koninckx PR. J Laparoendosc Adv Surg Tech A. 2011 Jul-Aug;21(6):539-40.


Postoperative inflammation in the abdominal cavity increases adhesion formation in a laparoscopic mouse model. Corona R, Verguts J, Schonman R, Binda MM, Mailova K, Koninckx PR. Fertil Steril. 2011 Mar 15;95(4):1224-8. Epub 2011 Feb 4.



The elephant in the room: quality control of endometriosis data.Koninckx PR, Batt RE, Hummelshoj L, McVeigh E, Ussia A, Yeh J. J Minim Invasive Gynecol. 2010 Sep-Oct;17(5):637-40.


Dietary fat consumption and endometriosis risk.Koninckx PR, Brosens IA. Hum Reprod. 2011 Mar;26(3):731-2; author reply 732. Epub 2010 Dec 21.



Laparoscopic management of ureteral lesions in gynecology. De Cicco C, Schonman R, Craessaerts M, Van Cleynenbreugel B, Ussia A, Koninckx PR. Fertil Steril. 2009 Oct;92(4):1424-7. Epub 2008 Oct 18.


Laparoscopic surgery for subfertility associated with endometriosis.Jacobson TZ, Duffy JM, Barlow D, Farquhar C, Koninckx PR, Olive D. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD001398. Review.

Laparoscopic surgery for pelvic pain associated with endometriosis. Jacobson TZ, Duffy JM, Barlow D, Koninckx PR, Garry R. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD001300. Review.

Hyperoxia and prevention of adhesion formation: a laparoscopic mouse model for open surgery. Binda MM, Koninckx PR. BJOG. 2010 Feb;117(3):331-9.


Accident analysis: factors contributing to a ureteric injury during deep endometriosis surgery. Schonman R, De Cicco C, Corona R, Soriano D, Koninckx PR. BJOG. 2008 Dec;115(13):1611-5;


Endometrium protection and acceptability of nasally administered continuously combined hormone therapy: a multicentre, multinational, double-blind trial in post-menopausal women evaluating three regimens of 17beta-estradiol and norethisterone when compared with an orally administered 17beta-estradiol norethisterone regimen. Rozenberg S, Pornel B, Koninckx PR, Palacios S, Christiansen C. Hum Reprod. 2009 Jul;24(7):1739-47.




Koninckx PR, Barlow D, Kennedy S. Implantation versus infiltration: the Sampson versus the endometriotic disease theory. Gynecol Obstet Invest. 1999;47 Suppl 1:3-9.


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