The genetic-epigenetic (G-E) aetiology of endometriosis
Endometriosis is a benign tumour following G-E incidents of a cell
- Thus the original cell is not important and can be endometrium, stem cells, or even bone marrow cells
- We are born with G-E defects which is our predisposition
- During life, we acquire more defects: above a threshold, endometriosis starts
The driving motors are pollution and oxidative stress by the blood of retrograde menstruation or by infection.
The G-E theory, for the first time, can explain ALL observations made on endometriosis, including the clonality and heterogeneity of lesions.
This theory is an update of my endometriotic disease theory of 1999.
The Sampson theory
In 1927 Sampson suggested that cells from retrograde menstruation could implant and develop. For a recent update, read GORDTS S et al . Since this could not explain all forms of endometriosis, the metaplasia theory was proposed, and later the hematogenic and lymphangitic spread.
The beginning of endometriosis lesions
All women are born with some genetic-epigenetic defects, which explains predisposing, the infertility, problems during pregnancy, and immunologic and other changes
Additional incidents occur during life because of pollution; oxidative stress of mainly retrograde menstruation and pelvic infection
Beyond a threshold of incidents endometriosis lesions initiate
- Thus each type of lesion has a different set of incidents
- Thus even similarly looking lesions can have very different sets of incidents e.g. progesterone resistance
Growth of endometriosis
- The set of G-E incidents determines the growth of typical, cystic or deep lesions
- Growth is moreover influenced by the immunology and the peritoneal fluid environment
- also, bleeding in the lesions will cause repetitive tissue trauma and repair (RETIAR)
- Most lesions grow for a certain time, but growth is self-limiting. When we make the diagnosis, most lesions are no longer growing; however, some are still growing and keep growing.
Clinical consequences of the G-E aetiology
- subtle endometriosis is normal endometrium implanted on the peritoneum and is not always a disease.
- each endometriosis lesion is G-E different like a benign tumour, and thus heterogeneous with a variable response to therapy
- the driving role of oxidative stress and of the peritoneal microbiome explains
- the importance of food intake
- the problem of repetitive retrograde menstruation
- how to organise prevention of endometriosis
- the importance of adolescent endometriosis
- Endometriosis therefore is
- not a recurrent disease : if removed completely there are no recurrences. New lesions however can develop.
- not a progressive disease in most women.
!! spurious associations
Endometriosis is NOT associated with cardiovascular disease
Historical Considerations of aetiology of Endometriosis
Cullen described already in 1880 rectovaginal endometriosis. Sampson described Cystic ovarian endometriosis in 1921. Because of endometriosis in women without a uterus, the metaplasia theory was proposed. Only after 1975 we realised that typical lesions were so frequent. In 1986 Janssens described the non-pigmented subtle endometriosis. The history of deep endometriosis starts with the paper of Cornillie and Koninckx in 1989
In 1921 Sampson proposed that menstrual cells that arrive in the peritoneal cavity by retrograde menstruation can implant and can develop further into endometriotic lesions. However, retrograde menstruation occurs in most women, and not all women develop endometriosis. This theory fails to explain why progression occurs in some women only or why endometriosis is hereditary.
Metaplasia theory is based on the fact that mesothelial cells in the peritoneum can be transformed by menstrual blood into endometrial cells. Progression and further development is identical to the implantation theory.
Haematogenic spread explains the occurrence of endometriosis in the lungs and on the pleura.
In deep endometriosis, endometrial cells are found in 50% of women in the lymph nodes. The significance of this is unclear.