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Images of endometriosis

 different diseases - severity - symptoms

 

Microscopy and activity of endometriosis.

Subtle endometriosis is morphologically very active
Typical endometriosis are inactive burnt out lesions
Cystic ovarian endometriosis is inactive with little endometriosis cells in the wall.
Deep lesions are superficially inactive but  morphologically active when deeper than 5mm

The activity of endometriosis is sometimes used as argument to consider subtle endometriosis as ‘severe’ since active

Deep endometriosis mophology

Deep endometriosis

Deep endometriosis

Deep endometriosis is active

Clinical types of endometriosis

Subtle endometriosis : small superficial endometriosis

In 1986 non pigmented lesions were recognized as endometriosis. Later they were called subtle lesions which were believed to be the early stages after implantation. They are small (1 to 3 mm) and look like white vesicles, red vesicles, polipoid  or flame like endometriosis.

Subtle endometriosis occur together with other lesions or  can hide more severe deep endometriosis. In the image below, subtle endometriosis covers a deep endometriosis lesion whereas a typical endometriosis is visible in the left uterosacral ligament.
Subtle lesion are very frequent and occur in up to 80% of a normal population. Subtle endometriosis can present very atypically and even mimic an ovarian cancer as shown below right. A frequent mistake is to mis-diagnose ‘endosalpingiose’ as endometriosis. Recently our understanding of subtle lesions was updated by understanding the progesterone resistance.

Typical endometriosis : 0.5-4 cm superficial lesions

Typical endometriosis or gunshot lesions are 1 to 2 cm or larger black puckered endometriosis in a white sclerotic area. These endometriosis are found in the pelvis and on the diaphragm.

Deep endometriosis can present as typical endometriosis.

Cystic ovarian endometriosis

Cystic ovarian endometriosis or chocolate cysts the ovary,  are  mostly 3-6 cm in diameter but can be much larger or smaller.
These cyst usually are fixed to the pelvic wall and other organs of the pelvis.
Stripping of the wall is the preferred technique since less recurrences. However, more recently superficial treatment was reconsidered see our recent publication  Medical therapy is ineffective
A cystic corpus luteum can mimic a cystic ovarian endometriosis

Deep endometriosis : solid tumors

Endometriosis can present as solid tumours up to 5 by 6 cm in diameter most frequently in the pouch of Douglas.
From the left picture it is obvious that this endometriosis is in close proximity of the vaginal wall, causing dyspareunia, and of the rectum, causing pain during bowel movement.
Other localizations are the sigmoid (not detectable clinically and easily missed during laparoscopy (except when the surgeon has great experience)and between the uterus and the bladder (hence bladder irritation and pain.

Deep endometriosis of the rectovaginal septum

rectoscopy is generally normal ; only the larger ones are felt

Deep endometriosis of the vesico-uterine fold  and the ureter

Deep endometriosis of the sigmoid

is easily missed during laparoscopy and is generally underestimated ; it is  difficult surgery.

Fot this reason we think that a contrast enema remains the only reliable method to judge occlusion

Adenomyosis

The definition is clear: endometrial stroma and glands in the myometrium. The prevalence varies between 30 and 70% according to the number of microscopical slides investigated .
There are 3 types of adenomyosis

  • thickening of the junctional zone
  • diffuse adenomyosis
  • nodular adenomyosis

Adenomyosis is a cause of pain and infertility

For a full discussion of adenomyosis read our recent article below

adenomyosis

click to read full article

The Ovarian remnant Syndrome : endometriosis

The ovarian remnant syndrome is fortunately rare. The literature is almost empty and I have not seen more than ten over the last 15 years. Diagnosis and surgery always are difficult.
The ovarian remnant syndrome should be thought of when a women following hysterectomy and ovariectomy has severe chronic pain, whereas at ultrasound (or other imaging techniques, a multi-cystic ovary is found with a suspicion of endometriosis). At laparoscopy as depicted below, almost invariably a frozen pelvis with encapsulated ovary is found : at dissection after identification of the ureter, is becomes immediately clear that the ureter is located inside the ovarian mass. Therefore the surgeon should be very experienced.

click for presentationovarian remnant

Peritoneal Pockets - Allen en Master syndrome

The pathophysiology of peritoneal pockets is  unclear but pockets are strongly associated with endometriosis.

The endometriosis can be different (spiders) and pockets were considered Müllerianosis

We recently described that pockets are an independent cause of pain and need teatment

article pockets

Read our recent paper

Haemorrhagic ascites Endometriosis

Endometriosis associated with haemorrhagic ascites is a rare condition and the abdomen can contain 6-10 litres. We believe as published the mechanism is similar to a Meighs syndrome 2008_ussia_ascites

Severity of endo

Ask what your doctor means with severe

  • Difficult surgery : deep endometriosis  > cystic ovarian endometriosis >> typical endometriosis
  • Often it means rAFS classes III and IV. However, when introduced deep endometriosis was not yet discovered, and deep lesions

Classifications

  • 1980 Acosta classification made a distinction between superficial and cystic ovarian endometriosis. Then Kistner which is similar
  • 1985 rAFS classification is a point scoring system. Classes I and II were superficial endometriosis, whereas III and IV cystic ovarian with adhesions,  as we described in 1991
  • 1986 Subtle lesions were described: after this many women which beforehand were classified as ‘normal’ now had  endometriosis.
  • 1990 we described deep endometriosis 
  • 2011 we published a review, which recently was translated into the ENZIAN classification and the new AAGL classification
2011_koninckx_ classification of endo

Our analysis how to classify endometriosis in 2011

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